Dr. Curtis

Dr. CurtisTheresa M. Curtis,
Professor 

Office: 1318 Bowers Hall
Lab: 1319 Bowers Hall
Phone: 607-753-2721
E-mail: theresa.curtis@cortland.edu

 




Education

SUNY Plattsburgh, B.S. in Biochemistry and Biophysics
Albany Medical College, Ph.D. in Physiology and Cell Biology

Professional Experience

University of Virginia School of Medicine, Postdoctoral Fellow
Agave BioSystems Inc., Staff and Senior Scientist

Courses Frequently Taught

Human Physiology
Anatomy and Physiology I and II
Biomedical Sciences Seminar

Scholarly Interests

The research in my laboratory focuses on using vertebrate cells in a variety of sensor configurations to detect chemical threats in the environment.  The ability to protect drinking water and food from the threat of accidental or intentional chemical exposure is becoming a growing need.  Sensitive analyte-specific chemical tests exist, but a large number of tests would be needed to detect all possible chemicals, and unknown chemicals or mixtures may escape detection.  To meet this growing need, my lab has been working of the development of a cellular-based biosensor to detect a broad range of agricultural and industrial chemicals.  Currently, we are screening a variety of vertebrate cells to understand both the chemical toxicant sensitivity and the longevity of the cells in the portable sensor platform.  Future efforts will be focused on transitioning more complex cell systems (organ- or body-on-a-chip systems) out of the laboratory and into the field to serve as sentinels in environmental monitoring applications.  The development of fieldable organ- or body-on-a-chip devices would closely predict human health effects and thus allow more reliable assignments of toxicity over systems currently used.

Funding

My team has been funded through the Department of Defense for over 10 years on projects including the development of: (1) vertebrate cell-based diagnostic assays for water toxicant sensing, (2) encapsulation technology for increased environmental stability of vertebrate cells for biosensor applications, (3) hand-held biosensors for rapid diagnosis and study of neural disease and neurotoxins, (4) portable cell maintenance system, (5) mast cell sensor for bacterial detection, (6) high-throughput wound healing assay for drug screening, and (7) antibody-based infectious disease diagnostic.

DOD/U.S. Army Phase II SBIR (Butler-PI)             $250,000                     2014-2016
A122-090-0468
U.S. Army Corps of Engineers
Encapsulation Technology for Increased Environmental Stability of Vertebrate Cells
Role: Subcontractor

SUNY Health Now Grant (Travis-PI)                      $10,000                       2014-2015
Development of Hand-held Biosensors for Rapid Diagnosis and Study of Neural Disease and Neurotoxins, represents collaboration between 5 SUNY institutions.
Role: Team member

DOD/U.S. Army Phase I SBIR (Butler-PI)              $25,000                       2013-2014
A122-090-0468
U.S. Army Corps of Engineers
Encapsulation Technology for Increased Environmental Stability of Vertebrate Cells
Role: Subcontractor

U.S. Army Contract (Curtis-PI)                               $77,147                       2011-2012
U.S. Army Center for Environmental Health Research
ECIS Evaluation of Additional Vertebrate Cell Lines for Chemical Sensitivity, Temperature Tolerance, and Shelf Life

U.S. Army Contract (Curtis-PI)                               $85,026                       2008-2010
U.S. Army Center for Environmental Health Research
Examination of Additional Cell Lines in ECIS System for Chemical Toxicant Detection

DOD/Army Phase II STTR (Curtis-PI)                    $750,000                     2005-2007
A045-028-0194                                                          
U.S. Army Center for Environmental Health Research
Portable Cell Maintenance System

DOD/OSD Phase I SBIR (Curtis-PI)                        $100,000                     2005
O043-H08-3058                                             
Walter Reed Army Institute of Research
Dipstick Assay for Field Detection of Leishmania Parasites using Quantum Dots

DOD/Army Phase I SBIR (Curtis-PI)                      $70,000                      2005
A043-071-1724                                                                                                                      
US Army Research Office
ECIS Wound Healing High-Throughput Assay

DOD/Army Phase II SBIR (Curtis-PI)                     $730,000                     2004-2005
A032-3868                                                     
U.S. Army Center for Environmental Health Research                                
Respiratory Endothelial Cell Sensor for Real-Time Air Toxicity Monitoring

DOD/Army Phase I STTR (Curtis-PI)                     $98,953                       2004
A045-028-0194                                              
U.S. Army Center for Environmental Health Research
Portable Cell Maintenance System

DOD/Army Phase I SBIR (Curtis-PI)                      $120,000                     2003
A032-3868-68271                              
U.S. Army Center for Environmental Health Research
Respiratory Endothelial Cell Sensor for Real-Time Air Toxicity Monitoring

NIH Postdoctoral Individual National Research Service Award (Curtis)
5F32HL010201-02                                                      $37,516                       2000
National Heart, Lung, and Blood Institute
Cell/Matrix Adhesive Interactions in Vasculogenesis

NIH Postdoctoral Individual National Research Service Award (Curtis)
1F32HL010201-01                                                      $31,720                       1999
National Heart, Lung, and Blood Institute
Cell/Matrix Adhesive Interactions in Vasculogenesis

Publications