Dr. Gatto

Dr. GattoLouis A. Gatto, Professor


Office: 1321 Bowers Hall
Lab: 1320 Bowers Hall
Phone: 607-753-2720
E-mail: louis.gatto@cortland.edu



Research Professor
Department of Surgery
College of Medicine
SUNY Upstate Medical University
Syracuse, NY

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Fordham University, M.S., Ph.D.

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  • Anatomy and Physiology I
  • Anatomy and Physiology II
  • Histology
  • Biological Literature

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Doctoral work focused on mucociliary transport in the trachea (supported by Grant HL-16730 from the National Heart, Lung, and Blood Institute of N.I.H).  Mucus clearance rates were measured in vitro and a novel methodology was developed for the measurement of viscosity, elasticity and adhesiveness of mucous secretions.  The objective of this work was to define mechanisms involved in the autonomic modulation of mucociliary clearance.

Subsequent research activities at SUNY/Cortland are shared with co-authoring students and involve the study of histochemical changes in tracheal glands and in the pH of tracheal mucus following pharmacological stimulation in several animal models.

Current research is carried out in liaison with the Surgery Department at SUNY Upstate Medical University College of Medicine at Syracuse, and involves the development of an animal model for the study of Adult Respiratory Distress Syndrome (ARDS).  The work at Syracuse entails the surgical instrumentation of a porcine sepsis model, while the subsequent histometric evaluation of lung tissues is done at Cortland.  The research team includes Cardiopulmonary Surgeons, Surgery Residents and Research Scientists from the College of Medicine, and the work closely parallels ARDS as it occurs in patients at the Intensive Care Unit at University Hospital.

We recently developed and patented an approach for treatment.  Gatto is  Co-Inventor in U.S. Patent No. 5,977,091 on "Method of Preventing Acute Lung Injury."  Assignee: The Research Foundation of SUNY.  U.S. Class: 514/152.  International Class A61K031/65. [http://www.uspto.gov/patft/index.html]


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Year 2012

Habashi N, Andrews P, Roy S, Sadowitz B, Nieman G, Gatto L.  "Up in smoke: Airway pressure release ventilation must be applied correctly to protect the lung."  Letter to the Editor.  Crit Care Med, 40(3): 1040-1041, 2012

Nieman G, Brown D, Sarkar J, Kubiak B, Ziraldo C, Dutta-Moscato J, Vieau C, Barclay D, Gatto L, Maier K, Constantine G, Billiar TR, Zamora R, Mi Q, Chang S, Vodovotz Y.  "A two-compartment mathematical model of endotoxin-induced inflammatory and physiologic alterations in swine."  Crit Care Med, 40(4): 1052-1063, 2012

Nieman GF, Gatto LA, Habashi N.  "Lung recruitment: The combined effect of pressures "North" and "South" of the diaphragm."  Editorial.  Crit Care Med, 40(6): 1985-1986, 2012

Roy SK, Kubiak BD, Albert SP, Vieau CJ, Gatto L, Golub L, Lee HM, Sookhu S, Vodovotz Y, Nieman GF.  "Chemically modified tetracycline -3 prevents acute respiratory distress syndrome in a porcine model of sepsis + ischemia/reperfusion induced lung injury"  Shock, 37(4): 424-432, 2012

Roy S, Sadowitz B, Andrews P, Gatto LA, Marx W, Ge L, Wang G, Lin X, Dean DA, Kuhn M, Ghosh A, Satalin J, Snyder K, Vodovotz Y, Nieman G, Habashi N.  Early stabilizing alveolar ventilation prevents acute respiratory distress syndrome: A novel timing-based ventilatory intervention to avert lung injury.  J Trauma Acute Care Surg 73(2): 391-400, 2012

Year 2011

Albert S, Kubiak BD, Vieau CJ, DiRocco J, Gatto LA, Young JL, Tripathi S, Roy SK, Trikha G, Lopez C and Nieman GF.  "Comparison of 'open lung' modes with low tidal volumes in a porcine lung injury model."  J Surg Res, 166(1):e71-81, 2011

Kubiak BD, Albert SP, Gatto LA, Vieau CJ, Roy SK, Snyder KP, Maier KG, Nieman GF.  "A clinically applicable porcine model of septic and ischemia/reperfusion-induced shock and multiple organ injury."  J Surg Res, 166(1):e59-69, 2011

Roy SK, Kendrick D, Sadowitz BD, Gatto L, Snyder K, Satalin JM, Golub LM, Nieman G.  "Jack of All Trades: Pleiotropy and the application of Chemically Modified Tetracycline -3 in Sepsis and the Acute Respiratory Distress Syndrome (ARDS)."  Pharmacol Res, 64:580-589, 2011

Sadowitz B, Roy S, Gatto LA, Habashi N, Nieman G.  "Lung injury induced by sepsis – lessons learned from large animal models and future directions for treatment."  Expert Rev Anti Infect Ther 9(12):1169-1178, 2011

 Year 2010

Dickinson GS, Piccone H, Sun G, Lien E, Gatto L and Alugupalli KR.  "Toll-like receptor 2 deficiency results in impaired antibody responses and septic shock during Borrelia hermsii infection."  Infect Immun, 78(11): 4579-4588, 2010

Kubiak BD, Albert SP, Gatto LA, Snyder KP, Maier KG, Vieau CJ, Roy S, Nieman GF.  "Peritoneal negative pressure therapy prevents multiple organ injury in a chronic porcine sepsis and ischemia/reperfusion model."  Shock, 34(5):525-534, 2010

Kubiak BD, Albert SP, Gatto LA, Trikha G, El-Zammar O, Nieman GF.  "Loss of airway pressure during HFOV results in an extended loss of oxygenation: A retrospective animal study."  J Surg Res, 162(2):250-257, 2010

Kubiak BD, Gatto LA, Jimenez EJ, Silva-Parra H, Snyder KP, Vieau CJ, Barba J, Nasseri-Nik N, Falk JL, Nieman GF.  "Plateau and transpulmonary pressure with elevated intra-abdominal pressure or atelectasis."  J Surg Res, 159(1): e17-24, 2010

Maggio D, Sadowitz B, Vieau C, Albert SP, Kubiak BD, Roy S, Gatto LA, Nieman GF.  "Titration of mean airway pressure and FiO2 during high frequency oscillatory ventilation in a porcine model of acute lung injury."  J Surg Res, 164(1): e147-153, 2010

Nieman G, Gatto L.  "Dynamic alveolar mechanics in acute lung injury.  Letter to the Editor."  Crit Care Med, 38(1): 344-345, 2010

Pérez-Fuentetaja A., Lupton S, Clapsadl M, Samara F, Gatto L, Biniakewitz R, Aga DS.  "PCB and PBDE levels in wild common carp (Cyprinus carpio) from eastern Lake Erie."  Chemosphere, 81(4): 541-547, 2010

Year 2009

Tripathi S, Bruch D, Gatto LA, Kittur DS.  "Green tea extract prolongs allograft survival as an adjunctive therapy along with low dose cyclosporine A."  J Surg Res, 154(1): 85-90, 2009

Year 2008

LaSpina M, Tripathi S, Gatto LA, Bruch D, Maier KG, Kittur DS.  “An interleukin-6-neutralizing antibody prevents cyclosporine-induced nephrotoxicity in mice.”  J Surg Res 148: 121-125, 2008

Year 2007

Halter JM, Steinberg JM, Gatto LA, DiRocco JD, Pavone LA, Schiller HJ, Albert S, Lee HM, Carney D, Nieman GF.  “Effect of positive end-expiratory pressure and tidal volume on lung injury induced by alveolar instability.”  Critical Care, 11(1): R20, 2007

Pavone LA, Albert S, Carney D, Gatto LA, Halter JM, Nieman GF.  "Injurious mechanical ventilation in the normal lung causes a progressive pathologic change in dynamic alveolar mechanics."  Critical Care, 11(3): R64, 2007

Pavone L, Albert S, DiRocco J, Gatto L, Nieman G.  "Alveolar instability caused by mechanical ventilation initially damages the nondependent normal lung."  Critical Care, 11(5): R104, 2007

Pavone LA, DiRocco JD, Carney DE, Gatto LA, McBride NT, Norton JA, Hession RM, Boubert F, Hojnowski KA, LaFollette RL, Dries DJ, Nieman GF.  "Absence of alveolar tears in rat lungs with significant alveolar instability."  Respiration, 74(4): 439-446, 2007


Year 2006

DiRocco JD, Pavone LA, Carney DE, Lutz CJ, Gatto LA, Landas SK, Nieman GF.  "Dynamic alveolar mechanics in four models of lung injury."  Intensive Care Med, 32(1): 140-148, 2006.

Halter JM, Pavone LA, Steinberg JM, Gatto LA, DiRocco J, Landas S, Nieman GF. "Chemically-modified tetracycline (COL-3) improves survival if given 12 but not 24 hours after cecal ligation and puncture."  Accepted for Publication in Shock

McCann UG, Lutz CJ, Picone AL, Searles B, Gatto LA, Dilip KA, Nieman GF.  "Whole blood cardioplegia (minicardioplegia) reduces myocardial edema after ischemic injury and cardiopulmonary bypass"  J Extra Corpor Technol, 38:14-21, 2006.

Swartz MF, Halter JM, Fink GW, Pavone L, Zaitsev A, Lee HM, Steinberg JM, Lutz CJ, Sorsa T, Gatto LA, Landas S, HareC, NiemanGF.  "Chemically modified tetracycline improves contractility in porcine coronary ischemia/reperfusion injury."  J Card Surg 21(3): 254-260, 2006.

Year 2005

Makarenko IG, Meguid MM, Gatto L, Chen C, Ramos EJ, Goncalves CG, Ugrumov MV.  "Normalization of hypothalamic serotonin (5-HT 1B) receptor and NPY in cancer anorexia after tumor resection: an immunocytochemical study."  Neurosci Lett, 383(3): 322-327, 2005.

Makarenko IG, Meguid MM, Gatto L, Goncalves CG, Ramos EJB, Chen C, Ugrumov MV.  "Hypothalamic 5-HT1B-receptor changes in anorectic tumor bearing rats."  Neurosci Lett, 376(2): 71-75, 2005.

Steinberg J, Halter J, Schiller H, Gatto L, Carney D, Lee H-M, Golub L, Nieman G.  "Chemically modified tetracycline prevents the development of septic shock and acute respiratory distress syndrome in a clinically applicable porcine model."  Shock, 24(4): 348-356, 2005.

Steinberg J, Halter J, Schiller H, Gatto L, Nieman G.  "The development of acute respiratory distress syndrome model after gut ischemia/reperfusion injury followed by fecal peritonitis in pigs: A clinically relevant model."  Shock, 23(2): 129-137, 2005.

Steinberg JM, Schiller HJ, Tsvaygenbaum B, Mahoney GK, DiRocco JD, Gatto LA, Nieman GF.  "Wood smoke inhalation causes alveolar instability in a dose dependent fashion."  Respir Care, 50(8): 1062-1070, 2005.

Year 2004

Gatto LA, Fluck R., Nieman GF.  "Alveolar mechanics in the acutely injured lung: Role of alveolar instability in the pathogenesis of ventilator-induced lung injury."  Respir Care, 49 (9): 1045-1055, 2004.

Steinberg JM, Schiller HJ, Halter JM, Gatto LA, Lee H-M, Pavone LA, Nieman GF.  "Alveolar instability causes early ventilator-induced lung injury independent of neutrophils."  Am J Respir Crit Care Med, 169(1): 57-63, 2004.

Year 2003

Halter JM, Steinberg JM, Schiller HJ, DaSilva M, Gatto LA, Landas S, Nieman GF.  "Positive end-expiratory pressure after a recruitment maneuver prevents both alveolar collapse and recruitment/derecruitment."  Am J Respir Crit Care Med, 167:1620-1626, 2003.

Makarenko IG, Meguid MM, Gatto L, Chen C, Ugrumov MV.  "Decreased NPY innervation of the hypothalamic nuclei in rats with cancer anorexia."  Brain Res, 961:100-108, 2003.

Schiller HJ, Steinberg J, Halter J, McCann U, DaSilva M, Gatto LA, Carney D., Nieman G.  "Alveolar inflation during generation of a quasi-static pressure/volume curve in the acutely injured lung."  Crit Care Med, 31(4):1126-1133, 2003.

Steinberg J, Halter J, Schiller HJ, DaSilva M, Landas S, Gatto LA, Maisi P, Sorsa T, Rajamaki M, Lee H-M, Nieman GF.  "Metalloproteinase inhibition reduces lung injury and improves survival after cecal ligation and puncture in rats."  J Surg Res, 111:185-195, 2003.

Year 2002

Darling E, Searles B, Nasrallah F, Robins M, You X, Gatto L, Clay N, Picone A, Steinberg J, Nieman G.  "High-volume balanced ultrafiltration improves pulmonary function in a model of post-pump syndrome."  J Am Extra-Corp Tech, 34:254-259, 2002.

McCann UG, Schiller HJ, Gatto LA, Steinberg JM, Carney DE, Nieman GF.  "Alveolar mechanics alter hypoxic pulmonary vasoconstriction."  Crit Care Med, 30(6)1315-1321, 2002.

Steinberg J, Schiller HJ, Halter JM, Gatto LA, Dasilva M, Amato M, McCann UG, Nieman GF.  "Tidal volume increases do not affect alveolar mechanics in normal lung but cause alveolar overdistension and exacerbate alveolar instability after surfactant deactivation."  Crit Care Med, 30 (12):2675-2683, 2002.

Year 2001

Carney D.E., McCann U.G., Schiller H.J., Gatto L. A., Steinberg J., Picone A.L., Nieman G.F. 2001.  "Metalloproteinase inhibition prevents acute respiratory distress syndrome."  J. Surg. Res., 99:245-252

McCann II U.G., Schiller H.J., Carney D.E., Gatto L. A., Steinberg J.M., Nieman G.F.  2001.  "Visual validation of the mechanical stabilizing effects of positive end-expiratory pressure at the alveolar level."  J. Surg. Res., 99:335-342

McCann UG, Schiller HJ, Carney DE, Kilpatrick J, Gatto L. A., Paskanik AM, Nieman GF. 2001. Invasive arterial blood pressure measurement in trauma and critical care: Effect of variable transducer level, catheter access and patient position.  Chest, 120(4):1322-1326.

Schiller H.J., McCann II U.G., Carney D.E., Gatto L. A., Steinberg J.M., and Nieman G.F.  2001.  "Altered alveolar mechanics in the acutely injured lung."  Crit. Care Med., 29(5):1049-1055.

Year 1999

Carney D.E., Bredenberg C.E., Schiller H.J., Picone A.L., McCann II U.G., Gatto L. A., Bailey G., Fillinger M., and Nieman G.F.  1999.  "The mechanism of lung volume change during mechanical ventilation."  Am. J. Resp. Crit. Care Med., 160:1697-1702

Carney D.E., Lutz C.J., Picone A.L., Gatto L. A., Ramamurthy N.S., Golub L.M., Simon S.R., Searles B., Paskanik A., Snyder K., Finck C., Schiller H.J. and Nieman G.F.  1999.  "Matrix metalloproteinase inhibitor prevents acute lung injury after cardiopulmonary bypass."  Circulation, 100:400-406.

Carney D.E., Lutz C.J., Picone A.L., Gatto L. A., Schiller H.J., Finck C.M., Searles B., Paskanik A.M., Snyder K.P., Edwards C., and Nieman G.F.  1999.  "Soluble tumor necrosis factor receptor prevents post-pump syndrome."  J. Surg. Res., 83:113-121

Lutz C.J., Carney D.E., Picone A.L., Schiller H.J., Gatto L. A., Snyder K.P., Paskanik A.M., and Nieman G.F.  1999.  "Videomicroscopy provides accurate in vivo assessment of pulmonary microvascular reactivity in rabbits."  Shock, 11(5):367-371

McCann II U.G., Gatto L. A., Searles B., Carney D.E., Lutz C.J., Picone A.L., Schiller H.J. and Nieman G.F.  1999.  "Matrix metalloproteinase inhibitor:  Differential effects on pulmonary neutrophil and monocyte sequestration following cardiopulmonary bypass."  J Extracorporeal Tech., 31(2):67-75.

McCann II U.G., Schiller H.J., Carney D.E., Gagne G.M., Thomas D., Hellwig B., Gatto L. A. and Nieman G.F.  1999.  "Alveolar recruitment as a mechanism of normal lung volume change:  Evidence from a novel nuclear imaging technique."  Surg. Forum, 50:155-157.

Nieman G.F., Searles B., Carney D.E., McCann II U.G., Schiller H.J., Lutz C.J., Finck C.M., Gatto L. A., Hodell M. and Picone A.L.  1999.  "Systemic inflammation induced by cardiopulmonary bypass:  A review of pathogenesis and treatment."  J. Extracorporeal Tech., 31(4):202-210.

Picone A.L., Lutz C.J., Finck C., Carney D.E., Gatto L. A., Paskanik A., Searles B., Snyder K., Nieman G.  1999.  "Multiple sequential insults cause post-pump syndrome.  Ann. Thorac. Surg., 67(4):978-985

Year 1998

Finck C.M., Hodell M.G., Marx W.H., Paskanik A.M., McGraw D.J., Lutz C.J., Gatto L. A., Picone A.L. and Nieman G.F.  (1998).  "Endotoxin-stimulated alveolar macrophage recruitment of neutrophils and modulation with exogenous surfactant."  Crit. Care Med., 26(8): 1414-1418.

Lutz C., Carney D., Finck C., Picone A., Gatto L. A., Paskanik A., Langenback E. and Nieman G.  (1998).  "Aerosolized surfactant improves pulmonary function in endotoxin induced lung injury."  Am. J. Resp. Crit. Care Med., 158:840-845

Lutz C.J., Picone A., Gatto L. A., Paskanik A., Landas S. and Nieman G.F.  1998.  "Exogenous surfactant and positive end-expiratory pressure in the treatment of endotoxin-induced lung injury."  Crit. Care Med., 26(8):1379-1389.

Year 1997

Lutz C., Picone A., Finck C., Searles B., Paskanik A., Hodell M., Lopez C., and Gatto L. A.  1997.  "Antiprotease treatment prevents postperfusion acute respiratory distress."  Surg. Forum, 48:309-311.

Year 1996

Nieman G. F., Gatto L. A., Paskanik A. M., Yang B., Fluck R., and Picone A.  1996.  "Surfactant replacement in the treatment of sepsis induced adult respiratory distress syndrome (ARDS) in pigs."  Crit. Care Med., 24(6):1025-1033.

Picone A., Gatto L. A., Nieman G. F., Paskanik A. M., and Lutz C.  1996.  "Pulmonary surfactant function following endotoxin:  Effects of exogenous surfactant treatment."  Shock, 5(4):304-310.